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Elegant studies inhibited central action of GLP-1R agonists by conjugating GLP-1R agonists to vitamin B12
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If there's insulin resistance, if there are, uh, metabolic comorbidities, like there's already pre-diabetes type two diabetes, fatty liver disease, there's elevated cardiovascular risk that [00:41:00] is not improving despite trying everything, doing everything right, then that's when GLP ones are considered
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